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The compound's sleep-promoting and related general physiological effects after intraventricular (brain), intravenous, and intraperitoneal application in different mammalian species have since been confirmed

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In the diet, lignans often occur as complex precursors (like secoisolariciresinol diglucoside in flax) that are metabolized by gut microbiota into bioactive forms (54)

For example, in a mouse model, low molecular weight AO (e.g., dimer and trimer) can significantly inhibit the long-term enhancement of hippocampal neurons and damage the spatial memory function