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Binding of the extracellular domain of an RTK to its cognate ligand leads to receptor dimerization and the activation of the intrinsic tyrosine kinase activity of its intracellular kinase domain
PINCH (which links ILK to the RTKs via Nck2)
SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth
FGFR family members differ from one another in their ligand affinities and tissue distribution
CLN6 (N258) Polyclonal Antibody-BS3102 Bioproduction Binding of the extracellular domainCLN6 (N258) Polyclonal Antibody Product: Rabbit IgG, 1mg ml in PBS with 0. 02% sodium azide, 50% glycerol, pH7. 2 Catalogue Numbers: BS3102 50, BS3102 100 Sizes: 50l, 100l Swiss Prot: Q9NWW5 Host: Rabbit Reactivity: Human, Mouse, Rat Applications: WB, IHC Background: CLN6, a 311 amino acid protein, has 7 predicted transmembrane domains and is conserved across vertebrates. The CLN6 protein localizes to the endoplasmic reticulum but contributes to
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