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We require improved evidence on pharmacokinetics, safety thresholds, and the effects of prolonged exposure

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2013), the vast majority of potential Nrf2 modulators are electrophiles with an inherent propensity to interact with off-target cellular nucleophiles

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As shown in Figure 2, 100% of the GSH is removed within 60 minutes

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and Mobli, Mehdi (2010)

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