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Shortened estrous cycle length, increased FSH levels, FSH variance, oocyte spindle aberrations, and early declining fertility in aging senescence-accelerated mouse prone-8 (SAMP8) mice: concomitant characteristics of human midlife female reproductive aging

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FSP1 (encoded by the AIFM2 gene), a NAD(P)H-dependent ubiquinone oxidoreductase, is a major means of ferroptosis control, acting independently of GPX4 by catalysing the reduction of ubiquinone to its hydroquinone form, ubiquinol, consuming NAD(P)H 4,5

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