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The Ozempic ladder reaches 2.0 mg weekly, but doubling from 1.0 to 2.0 mg added only about 0.23 percentage points of HbA1c reduction and 0.9 kg of weight loss. Beyond 1.0 mg, most of the added effect is on weight rather than glucose

I think the combination of the B12 and the semaglutide make it a great way to lose weight and help with the side effects

Hyperglycemic crises and related neurological sequelae including seizures and altered consciousness may link to suboptimal glycemic control during GLP-1 RA therapy

If patients are eating less and potentially consuming less B12-rich food, supplementing directly alongside the semaglutide injection ensures adequate intake without requiring a separate oral supplement