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The expression level of GSK-3 and collapsin-responsive mediator protein-2 (CRMP-2) were raised after seizure induction

These compounds obtained from natural sources, eg, plants, animals, minerals, and microorganisms, are grouped as natural products (NPs) scientifically

After a comparison with the known IRAP structures and a combination with small angle X-ray scattering experiments it was proposed that IRAP is an open dimer in solution and assumes a more compact conformation upon HA08 binding