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The following relevant parameters were determined where possible: area under the concentration-time curve from time zero to the last time point (AUCo-iast) or extrapolated to infinity (AUCo- ), C ma x concentration in plasma extrapolated to time zero (Co), terminal elimination half-life (tj 2), volume of distribution (Vd), and clearance (CL)

This method is frequently coupled with statistical tools such as non-metric multidimensional scaling (NMDS) and analysis of similarities (Anosim), which provides an additional dimension of data visualisation, enabling a more comprehensive understanding of microbial diversity and clustering patterns [182, 183, 193, 207, 283, 306]

Graft-versus-leukemia effect after allogeneic bone marrow transplantation for chronic lymphocytic leukemia