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This downregulation is linked to reduced O-GlcNAcylation, hyperphosphorylation of Tau, and increased density of NFTs [141]

No notable side effects have been reported during Selank studies that were definitively correlated with the peptide treatment

[1] Unlike amphetamine abuse, where drug tolerance necessitates escalating doses to achieve the same effect, tolerance to clinically relevant doses of amphetamine plateaus after the initial titration period, and "drug holidays" (i.e., temporary treatment discontinuation) are not required to prevent the development of tolerance

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