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The level of GSH/GSSG in the cells treated with NS for more than 6 h was also significantly decreased, but the extent was smaller than that in the NSBSO group, indicating that the combination of consumption of existing GSH and inhibition of GSH synthesis promotes the exhaustion of GSH in cells

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175 Wnt/-catenin signalling pathway in non-tumour liver diseases The cholestasis Wnt/-catenin pathway decreases bile acid (BA) synthesis, preventing the development of cholestatic liver injury and fibrosis after bile duct ligation (BDL)

It depends on the individual response and lifestyle changes made simultaneously