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These approaches have led to significant weight loss with the dual GLP-1/glucagon receptor agonist survodutide (-13.5% with the 6-mg dose at 76 weeks in a phase 3 SYNCHRONIZE-1 trial) [16] , the dual GLP-1 receptor agonist and GIP antagonist Maridebart cafraglutide (known as MariTide) (-12.3% to -16.2% across different doses at 52 weeks in a phase 2 trial) [17] or the triple GLP-1/GIP/glucagon receptor agonist retatrutide (-24.2% with the 12-mg dose at 48 weeks in a phase 2 trial) [18]

That is the closest thing to human efficacy data the peptide research space currently has for a gut indication

Long-term use of extremely high doses could potentially disrupt kidney or liver function, especially in people with existing health conditions

Shelf life after reconstitution Reconstituted retatrutide in bacteriostatic water maintains potency for approximately 28 to 30 days when stored properly at 2 to 8 degrees Celsius