DSIP crosses the blood-brain barrier freely an unusual property for a peptide of its size via a non-competitive, non-saturable passive mechanism whose physicochemical determinants (lipophilicity, charge, molecular weight, and protein-binding) are now well characterised
Each has its own strengths and limitations in terms of formulations available, pricing, shipping speed, and geographic coverage
For pernicious anaemia or neurological involvement, maintenance injections are typically given every two to three months indefinitely
(3) M Bex, R Abs, D Maiter, et al (2002) The effects of growth hormone replacement therapy on bone metabolism in adult-onset growth hormone deficiency: a 2-year open randomized controlled multicenter trial Journal of Bone Mineral Research, 2002 Jun, Volume 17 (Issue 6), Pages 1081-94