Conversely, dysbiosis of gut microbiota could enhance susceptibility to pulmonary diseases and potentially act as causative agents for respiratory infections
However, when Cys 129 residue of PTPN22 is mutated, the disulfide bond cannot form and the enzyme is exposed by oxidation, resulting in inactivation (93)
Other secondary causes of cognitive impairment, including genetic disorders (e.g., Wilsons disease), autoimmune conditions (e.g., SLE), chronic epileptic syndromes, repetitive head trauma (e.g., chronic traumatic encephalopathy) [501], and neoplastic processes or their treatments (e.g., chemotherapy-related cognitive impairment or brain fog) [502], are similarly well defined
Over time, the brains cooling system wears down, leading to agitation, poor sleep, and cognitive fatigue