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The AASLD-IDSA HCV Guidance states that recent or active injection drug use or alcohol use is not a contraindication to HCV treatment and requirements for pretreatment screening for illicit drug or alcohol use should be discontinued.[2] Nevertheless, for persons with chronic HCV infection, substance use, either past or present, which encompasses the use of opioids, amphetamines, cannabis, cocaine, alcohol, and other drugs, may still be relevant to the individual's overall health and medication access