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As expected, H 2 O 2 (0.2 mM) exposure disrupted cellular glutathione homeostasis in both HepG2 cells (a human hepatoma cell line) and NCTC1469 cells (a non-transformed mouse hepatocyte cell line), as demonstrated by an increase in the GSSG/GSH ratio over time (Fig

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However, better characterization of IL-22 effects in MASH, as well as determination of the disease stage at which Th22 responses are most significant, may help clarify whether enhancing the activity of this subset is a viable therapeutic strategy

Over time, this only weakens the adrenals as well as the other systems involved