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The EAGLES trial, a double-blind, randomised, placebo-controlled clinical trial, showed that varenicline is more efficacious in achieving higher abstinence rates compared to bupropion (odds ratio [OR] 1.75), nicotine patch (OR 1.68) and placebo (OR 3.61).[15] Contrary to many concerns, the study did not show a significant increase in neuropsychiatric adverse events attributable to varenicline or bupropion compared to nicotine patch or placebo