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Given the role of angiogenesis in the growth and/or maintenance of neurovascular units in the nervous system, a role for abnormal angiogenesis in neurodegenerative diseases has been hypothesized and aberrant angiogenesis has been proposed as a potential factor in the progression of neurodegenerative diseases (Parkes et al

Furthermore, caffeine decreased subjective sleepiness and influenced EEG amplitude across various brain regions, suggesting that this combination deserves deeper exploration in the context of caffeine administration timing in cirrhosis (34, 36)

Additional markers to consider: oxidative stress markers (8-isoprostane, malondialdehyde), inflammatory markers (hsCRP, IL-6), liver function tests

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