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Additionally, intravascular hemolysis results in renal injury, which develops as a consequence of filtering hemoproteins released from hemolytic red cells by the kidneys [229]

These events occurred at similar rates in placebo groups, suggesting they may not be directly attributable to the peptide

In published clinical trials, once weekly cagrilintide has been reported to produce dose dependent body weight reductions in participants with overweight or obesity, and it has also been studied in combination programmes with semaglutide, where trials reported greater weight loss than either component alone

To address this, other forms have been developed