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Appetite suppressants and B12 injections require in-office visits

Safety profile Cardiorenal effects Slight increases in heart rate have been reported with the GLP-1 RAs in certain populations, 60 but the cardiac benefits of using these drugs have been widely investigated

Upregulation of HLADR, intercellular adhesion molecule-1 and E-selectin activates CD2+, CD3+, CD5+, CLA+, CD45RO, HLA-DR, CD25 (IL-2 receptor) and CD27 expressing T cells [2]

Future efforts in the LCINS space include identifying a population with elevated germline and/or exposure-mediated risk to prioritize for LDCT screening (for example, individuals carrying large-effect rare variants associated with familial EGFR -mutant lung cancer), with studies already under way (such as NCT05587439 and NCT05265429)