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The principle of PDT therapy depends on the production of ROS, photo-oxidation of target cells, and their death

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Dosing & Reconstitution Guide Educational guide for reconstitution and daily dosing Standard / Gradual Approach (2 mL = 300 mg/mL) Frequency: Inject once daily subcutaneously, or split into every-other-day dosing based on protocol goals [5]

Mechanistically distinct from other forms of cell death, cuproptosis is characterized by the direct binding of copper to lipoylated enzymes in the mitochondrial tricarboxylic acid (TCA) cycle, leading to proteotoxic stress and subsequent cell death, independent of classical apoptotic signaling [3]