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This doesn't mean they're dangerous or ineffective, but it does mean: Limited clinical data: Without the trials required for approval, human data remains sparse

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People who have had surgery to remove the stomach or the end of the small intestine may also not be able to absorb vitamin B12

After the first puncture, bacteriostatic water is commonly stored at 28C (3646F) and used within the discard period specified on the manufacturer label, often around 28 days in clinical practice