As a specific class of ROS, excessive lipid peroxidation can disrupt plasma membrane integrity and further trigger multiple cell death modalities, including ferroptosis, apoptosis, necroptosis, pyroptosis, parthanatos, autophagy, cuproptosis, lysosomaldependent cell death, and NETosis [114]
Karuppagounder SS, Alin L, Chen Y, Brand D, Bourassa MW, Dietrich K, Wilkinson CM, Nadeau CA et al (2018) N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E 2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice
The flavonoid glycoside icariin has been shown to increase the expression of Nrf2, HO-1, and GPX4, in cisplatin-treated mouse ovarian tissues and KGN cells, which may contribute to reduced OS and ferroptosis (Li F
Now, here is the surprising thing