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Key References Key References 1

Symptoms of folate deficiency Some of the symptoms that can be caused by a lack of folate include: General symptoms Fatigue Irritability Headache Dizziness Gastrointestinal symptoms Sore tongue Mouth ulcers Diarrhea Loss of appetite Neurological symptoms Numbness and tingling in the hands and feet Confusion Depression Cognitive impairment Dementia Hematological symptoms Anemia (pale skin, shortness of breath) Testing for vitamin B12 and folate deficiency When to test Since vitamin B12 and folate affect many functions in the body and there are many possible symptoms, blood testing for vitamin B12 and folate is commonly ordered by the physicians at the Adult Down Syndrome Center

Taking too much of some B vitamins may have adverse effects, like diarrhea, rashes, and headaches

The researchers compared the three primary B12 delivery methods and found the following mean increases in serum B12 levels: A p-value of 0.270 means there is no statistically meaningful difference between the three methods