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of note, the proportion of non-smokers who started using electronic smoking devices was rather low.7 Recent data from the Behavioural Risk Factor Surveillance System (BRFSS) suggest that the use of electronic cigarettes is increasing among never-smokers, to nearly 2 million US adults in 2016.8 The mean prevalence of never-smokers who smoked electronic cigarettes at least once ranges from 0.1 to 3.8%.7,9,10 Those electronic cigarette users who have never smoked conventional cigarettes are defined as sole electronic cigarettearette users in the literature

Smoking rates have both plummeted and spiked worldwide The proportion of the total global population that smokes decreased 42 percent for women and 25 percent for men between 1980 and 2012

Severe nicotine poisoning from ingestion can cause nausea, vomiting and arrhythmias, and can even progress to seizures, respiratory depression and death

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