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In 1973, the figure rose to about five hundred and eighty-five billionthe biggest annual consumption of cigarettes in history

In smokers, a single dose of the xanthine oxidase inhibitor allopurinol restores the acetylcholine-induced endothelium-dependent relaxation response in forearm arteries to nonsmoker levels but does not affect the endothelium-dependent relaxation response in nonsmokers [73]

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