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The classic presentation of this condition is as follows: Intense immediate pain at injection Livedoid discoloration (mottled, dusky appearance) Rapid ecchymosis (bruising) Blistering and eventual skin necrosis This requires emergency specialist care

The much larger, headline-grabbing numbers associated with cagrilintide in the press figures in the low-to-mid 20% range come from Phase 3 trials of CagriSema , the combination with semaglutide, and are company-reported topline results, not standalone-cagrilintide data and not the peer-reviewed Phase 2 result cited above

Extended data Extended Data Fig

No two plans are the same