White-matter changes appear to be asymmetrical and present in the earliest stages of bipolar illness, most likely indicating abnormal expression of myelin- and oligodendrocyte-related genes (128131, 133, 134)
Such unwanted side effects include undesired tachycardia, increased lactic acidosis, cardiac arrhythmias (including atrial fibrillation) as well as the development of refractory shock (DeBacker et al, 2010
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The autoimmune inflammatory environment in SLE may train HSPCs to produce hyperresponsive myeloid cells, further promoting autoantibody generation and organ damage, and potentially driving maladaptive progression (91)
