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For instance, curcumin significantly reduced histopathological damage and improved general symptoms in experimental colitis, accompanied by increased the expression of Treg cells and decreased the expression of Th17 cells as well as increased the expression of anti-inflammatory cytokines such as IL-10 and decreased the expression of proinflammatory cytokines such as IL-17A, IL-1, IL-6, IL-33, CCL-2, IFN-, and TNF- [264, 266, 267]

J Biol Chem 294:1610916122 Mahran YF (2020) New insights into the protection of growth hormone in cisplatin-induced nephrotoxicity: the impact of IGF-1 on the Keap1-Nrf2/HO-1 signaling

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(136) investigated the preventive effects of phenolic metabolites in S