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Similarly, activation of mitochondrial CB 1 Rs with THC resulted in reduced glycolytic activity and lactate production in primary cultured astrocytes (01-days-old), which was hypothesized to contribute to the subsequent impaired neuronal function and altered behavior (e.g., social interaction deficit) in young adult (812-weeks-old) mice (Jimenez-Blasco et al., 2020)

Y., Valverde N., and Claros S., New Molecular Mechanisms to Explain the Neuroprotective Effects of InsulinLike Growth Factor II in a Cellular Model of Parkinson's Disease, Journal of Advanced Research 67 (2025): 349359

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