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Cancer 123 PoppeD.TiedeI.FritzG.BeckerC.BartschB.WirtzS.et al (2006)

After entering the brain parenchyma, monocytes differentiate into macrophages under the regulation of the local microenvironment, with the pro-inflammatory M1 phenotype activated by signals such as IFN- and TNF- to release inflammatory cytokines and nitric oxide (NO) for antimicrobial functions, while the anti-inflammatory M2 phenotype is induced by IL-4, IL-10, TGF-, and macrophage colony-stimulating factor (M-CSF) to participate in tissue repair through the production of extracellular matrix components and angiogenic factors (84)

Phase 2, Proliferation (Days 5-21): BPC-157 drives fibroblast proliferation and collagen synthesis

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