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UOC Mitochondrial dysfunction in neurodegenerative diseases (Grant Code 377226)

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Side effects from B12 supplementation are uncommon but may include: Mild gastrointestinal symptoms such as nausea or diarrhoea, typically with very high oral doses Headache or dizziness in some individuals Skin reactions (rash, itching) at injection sites when using intramuscular preparations Rare but serious allergic reactions, including anaphylaxis with injectable forms Hypokalaemia (low potassium) may occur during rapid correction of severe megaloblastic anaemia If you experience symptoms of a severe allergic reaction (difficulty breathing, severe rash, swelling of face or throat) after taking B12, seek immediate medical attention

[168] showed that the ability of PET fragments to interact with cell membranes is strongly size-dependent: PET monomers readily inserted into phospholipid bilayers from the aqueous phase, whereas PET tetramers did not penetrate the membrane, implying higher passive-diffusion potential and thus greater bioavailability for smaller particles