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In a study in the 5XFAD mouse model of AD, microbial dysbiosis was noted to be associated with activation of the endolysosomal CCAAT/enhancer-binding protein- (C/EBP-) asparagine endopeptidase (AEP) pathway (Chen et al., 2020)

TB-500, a synthetic analog of thymosin beta-4, and BPC-157, a pentadecapeptide derived from gastric juice, are studied for their biochemical properties and effects on tissue models in vitro and in vivo within controlled laboratory environments

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The rapid proliferation of peptide therapies in recent years has outpaced the traditional clinical trial process