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Metabolic products such as lactate produced by neutrophils through aerobic glycolysis can reversely amplify macrophage M1 polarization and the release of pro-inflammatory mediators, forming a immune infiltration - metabolic abnormality - inflammation amplification feedback loop to indirectly promote metabolic reprogramming (48, 53, 54)

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LDH is largely found in all body cells and has a direct role in energy metabolism

Ghrelin helps turn down something called somatostatinan inhibitor of GH