The existing MetS-associated animal models induced by high-fat diets are mainly rodent models, including (diabetic ED rats, hyperlipidemic ED rats, etc.), which may only lead to obesity or insulin resistance, but lack key manifestations such as hypertension or inflammation
Gungor L, Polat M, Ozberk MB, et al
Dai L., Zou L., Meng L., et al., Cholesterol Metabolism in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets, Molecular Neurobiology 58, no
While the study establishes a compelling systemic role for SLC25A45 in fuel switching, important questions remain regarding the tissue-specific contributions of this pathway and how carnitine biosynthesis and utilization are differentially regulated across dietary, disease, and sexually dimorphic contexts