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DSIP was first characterized by Marcel Monnier and colleagues at the University of Basel, Switzerland, arising from a series of cross-circulation experiments in which blood from a sleeping rabbit was transferred to an awake recipient, causing measurable changes in the recipient's EEG brainwave patterns consistent with delta-wave sleep induction

Endotoxemia Lipopolysaccharide (LPS) is a major component of the outer membrane of all gram-negative bacteria that can trigger the synthesis and release of pro-inflammatory cytokines such as TNF, interleukin 1 (IL-1), and inducible nitric oxide synthase (iNOS) (Zhang et al., 2000

The pancreas is a vital organ with two main functions: producing insulin to manage blood sugar (endocrine function) and creating digestive enzymes to break down food (exocrine function)

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