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As both IBD and PD have compromised intestinal barrier functions, DJ-1 deficiency promotes cytokine-mediated inflammation (IL-1, IL-6, TNF, and TGFB1) and apoptosis of intestinal epithelial cells via a p53-dependent mechanism in vitro , in ex vivo colonic sacs, and in vivo (van IJzendoorn and Derkinderen, 2019

Khazaei, S

I've not had them for the past few months due to lack of funds and I've really really missed them, it's not a cure and it doesn't stop all fatigue but with persistence, pacing and taking care they can really enhance life and take the edge off that crippling fatigue where you can't stand up

BMC Endocr Disord 23 , 13 (2023)