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HGC-27 cells exhibit heightened sensitivity to erastin upon overexpression of cytoplasmic polyadenylation element binding protein 1 (CPEB1), which in turn reduces twist1 expression and activates the ATF4/ChaC glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) pathway [96]

ACE2 is expressed in most human tissues and cell types as a type I integral membrane protein solubilized by the action of a disintegrin and metallopeptidase (ADAM)-17 293

The ratio of GSH to GSSG is a direct indicator of cellular redox status, and when that ratio shifts, it signals oxidative stress