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There are no reported risks associated with large doses of B12, since the vitamin is water soluble and excess amounts are flushed out of the system

Our team recommends laying everything out on a sterile surface or a disinfected lab bench

Sarah Taylor, PhD Published October 29, 2025

Primary Care Guidelines for B12 and Folate Testing Indications for B12 and Folate Testing No need to check B12 levels in patient on parenteral B12 treatment (they will always be high) There is no indication to check GPA or INF purely because of family history of autoimmune disease or hypothyroidism Care should be taken when prescribing folic acid alone If folic acid is given to a patient who is actually b12 deficient, this may precipitate irreversible neurological complications References 1