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Analytical Chemistry, 95 , 1869118696

It is well established that most of the known glycolytic enzymes are modifiable by these species, with the highest modification potential being for phosphofructokinase (PPK) and glyceraldehyde-3-phosphate dehydrogenase (GA3PDH) (Reijenga et al., 2002)

1986a;261:62166221

Here, we discuss the increasing evidence for redox dysregulation as an important and primary contributor to ALS pathogenesis, which is associated with multiple disease mechanisms