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Antagonists of growth hormone-releasing hormone (GH-RH) reduced prostate size in experimental BPH 46 , and we previously showed that potent synthetic antagonists of GH-RH strongly inhibit the growth of diverse experimental human tumors including prostate cancer by suppressing various tumoral growth factors 47,48

doi: 10.3389/fpls.2022.958490 Received 31 May 2022 Accepted 27 July 2022 Published 16 August 2022 Volume 13 - 2022 Edited by Cecilia Gotor, Institute of Plant Biochemistry and Photosynthesis (CSIC), Spain Reviewed by Mirko Zaffagnini, University of Bologna, Italy

The no-DAC form (often called mod GRF 1-29) lacks this complex and is short-acting, clearing in minutes like native GHRH