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While the percentage of T-helper cells ( Figure 6A ) decreased from d 42 ap until 4 h pp and then stayed at the initial level until the end of the trial, the percentage of cytotoxic T-cells ( Figure 6A ) as well as the ratio of CD4 + to CD8 + ( Supplementary Table 4 ) fluctuated in an undirect manner over time

(4) reported that an 8-week UA intervention led to a significant reduction in pain responses in a murine model of osteoarthritis