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PCBs (polychlorinated biphenyls, industrial chemicals now banned but still present in the environment), DDT/DDE (a legacy pesticide and its primary breakdown product), and PBDEs (polybrominated diphenyl ethers, used as flame retardants) concentrate in animal fat and accumulate further up the food chain

A multicentre retrospective study of 499 patients identified ICI patients with renal cell carcinoma (RCC) in which 80 patients developed severe irAEs warranting treatment cessation, 36 of whom were able to be restarted on an ICI agent and 44 permanently discontinued

J Immunol (2011) 186(6):374552

Additionally, incorporating a moisturizer can help alleviate dryness and peeling