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Free Radic Biol Med 194:245254

We also discuss how pain is influenced by our emotions, stress and memories, and practical tools to control ones psychological perception of pain

55,57 In a randomized, double-blind, crossover trial in 42 patients with primary open-angle glaucoma or ocular hypertension being treated with timolol eye drops and whose IOP was between 19 and 24 mm Hg, the addition of 600 mg oral PEA per day (300 mg twice daily) for two months led to a significant reduction in IOP compared with placebo

You should discuss the regulatory status, expected benefits, and risks with your provider before starting treatment