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Avoiding high-fat foods during the adaptation phase helps, as fat slows digestion further and can worsen discomfort

The results were significant: At 48 weeks, participants receiving the 12 mg dose achieved a mean weight reduction of 24.2% (approximately 58 pounds or 26.2 kg) 100% of participants on the 8 mg or 12 mg doses lost at least 5% of their body weight More than 90% of participants on the 12 mg dose lost at least 10% of their body weight Nearly half of participants on the highest dose lost 25% or more of their body weight The study also showed improvements in cardiometabolic markers including blood pressure, triglycerides, LDL cholesterol, and fasting glucose

Choong et al, 2005)

Vitamin B12 is an essential water-soluble vitamin that plays an important role in many functions in the body