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The presence of high serum bicarbonate could indicate chronic respiratory acidosis [typical of chronic obstructive pulmonary disease (COPD)] or metabolic alkalosis (secondary to vomiting, use of thiazide diuretics, or excess mineralocorticoids) (336)

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Crypts were then mechanically separated from the connective tissue by shaking, and filtered through a 70 m mesh into a 50 mL conical tube to remove villus material and tissue fragments

In coronary arteries, decreased reactivity to endogenous NO and decreased production of endogenous NO itself have also been noted in smokers [56]