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Inhibition of CDK11 for 30 min fully abrogated the phosphorylation of SF3B1 as well as phosphorylation of Thr806 in SPT5, a recently identified CDK11 substrate 74

Experiments using a cell-based small-molecule screening and quantitative proteomics, revealed the potential of piperlongumine, a natural product isolated from the plant species Piper longum L , as a cytotoxic agent triggering apoptosis and necrosis in leukemia cells ( in vitro and in vivo but not primary normal cells (Raj et al., 2011)

In many cases, protein glutathionylation was observed in an endogenous milieu, but its functional change and physiological impact were not studied

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