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Furthermore, a reduction in NAD levels would result in decreased activity of sirtuins, such as SIRT3 (mitochondrial sirtuin), leading to less deacetylation and, consequently, less activation of SOD2 (210)

The mitochondrial fission mechanism ensures the quality of the mitochondrial population by removing damaged or disabled members in a timely manner, whereas mitochondrial autophagy further removes damaged parts and prevents deeper cellular injury when the cell is under severe stress [54]

Genetic studies in patients and mouse models have shown that alopecia areata is a complex, polygenic disease

15,72 ACSL4 facilitates the transformation of free PUFAs into acyl-CoA derivatives known as PUFA-CoAs