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It has emerged as a potential solution to combating health issues related to growth hormone deficiency due to its ability to stimulate: The release of growth hormone (GH) The production of insulin-like growth factor 1 (IGF-1) These mechanisms are crucial to the promotion of muscle growth and fat metabolism [2]

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Additionally, HO-1-derived BL and CO have been shown to upregulate brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor expression in both neurons and astrocytes, thereby facilitating proper DA neuron development ( 3 Discussion Bilirubin, as an endogenous metabolite, is gaining increasing attention for its multi-target protective effects in PD