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Realizing this potential requires addressing critical gaps: although preclinical studies highlight innovative mechanisms (e.g., multimodal therapies and stimuli-responsive release), robust clinical validation remains scarce, necessitating phase I/II trials to confirm efficacy and safety

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Activating these receptors in the pituitary gland (growth hormone secretagogue receptors) promotes the release of growth hormone (GH)

This means it can address aspects of appetite regulation that semaglutide alone may not fully control