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But chronic high-dose use may: Overstimulate metabolic pathways Alter methylation balance (since NNMT is tied to methyl donor cycling) Lead to unintended side effects like fatigue, irritability, or hormonal imbalance Stick to researched dosing windows (typically 1020 mg/day for short cycles in animal models) 2

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Utilizing the chicken chorioallantoic membrane (CAM) assay and endothelial tubule formation assay, studies demonstrated that BPC 157 could augment vascular proliferation both in vivo and in vitro (Hsieh et al

Thats partly so that humans are not put at risk, but its also because research on animals is much less expensive to do