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514 Targeting translation and epigenetic regulation Transcriptional and translational studies have provided a scientific foundation for the discovery of drug targets for underlying mechanisms, such as PI3K/mTOR pathways

Large doses of folic acid may also partially mask or worsen vitamin B deficiency by correcting anemia while allowing neurological damage to progress

AJP: Renal Physiology

The slow intravenous infusion protocols used in clinical trials minimized these effects, suggesting that rapid bolus administration (which is essentially what subcutaneous injection creates) may increase the likelihood of transient side effects